| abstract |
The invention relates to the compounds of formula (I); where p is 1, 2 or 3; X is O or CH2; Y is O, CH2 or is absent; Z1, Z2, Z3, and Z4 are each independently N or CH; A is inter alia oxazole, thiazole; Useful for the treatment of disorders mediated by acyl-CoA-diacyl-glycerol acyl transferase 1 (DGAT1), eg metabolic disorders. The invention also provides methods for the treatment of disorders, and compositions for their treatment Specific compounds are: 2- (4- (4- (5- (5-tert-butyl-1, 3,4-oxadiazole-2 -ilamino) pyridin-2-yl) phenyl) -2-oxabicyclo [2.2.2] octan-1-yl) acetic; 2- (4- (4- (5 - ((5-cyclobutyl-1, 3,4-oxadiazol-2-yl) amino) pyridin-2-yl) phenyl) -2-oxabicyclo [2.2.2] octane acid -1-yl) acetic; among others. |