| abstract |
The present invention relates to spirocyclic compounds of formula (I) wherein ring A is C3-C10 cycloalkyl, among others; L is O or NR4; W is N or CR5; X is N or CR6; Y is N or CR7; R1 is H, C1-C10 alkyl, among others; R2 and R3 are H, C1-C4 alkyl and C1-C4 haloalkyl; RA is H, halo, among others; RB is H, halo, among others; RC and RD are H, halo, among others; n is 1 or 2. Preferred compounds are: (S) -8- (2-amino-6 - ((R) -2,2,2-trifluoro-1- (3- (3-methiI-1H-pyrazole) acid -1-yl) -4 '- (methylthio) - [1,1'-biphenyl] -4-yl) ethoxy) pyrimidin-4-yl) -2,8-diazaspiro [4.5] decane-3-carboxylic acid (S) -8- (2-amino-6 - ((R) -1- (3'-carboxy-3- (3-methyl-1H-pyrazol-1-yl) - [1,1'-biphenyl] -4-yl) -2,2,2-trifluoroethoxy) pyrimidin-4-yl) -2,8-diazaspiro [4.5] decane-3-carboxylic, among others. Said compounds are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1, being useful in the treatment of diseases related to peripheral serotonin, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory diseases, among others and cancer. |