| abstract |
Referring to thienopyrimidine derivatives of formula I, where: R1 is -C(=O)N(R3)(R4); R2a and R2b are H; R2c is H or halogen; R2d is H, halogen, etc.; R3 is C1-C6alkyl, C1-C6alkoxy, among others; R4 is C1-C4alkyl, among others. Preferred compounds are: (7S)-4-(1H-indazol-5-ylamino)-N,N-dimethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-7- carboxamide; Azetidin-1-yl[(7S)-4-(1H-indazol-5-ylamino)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-7-yl]methanone, among others. said compounds inhibit MKNK1 and MKNK2, being useful in the treatment of hyperproliferative disorders and/or angiogenesis. |