| abstract |
REFERS TO COMPOUNDS DERIVED FROM TRIAZOLONE OF FORMULA I AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, CHARACTERIZED BECAUSE A1 IS PHENYL OR A 6-MEMBER HETEROAROMATIC RING CONTAINING 1, 2, or 3 N ATOMS; A2 IS A2a OR A2b, WHERE A2a IS PHENYL OR A 6-MEMBER HETEROAROMATIC RING CONTAINING 1, 2, or 3 N ATOMS; AND A2b IS A HETEROAROMATIC RING OF 5 MEMBERS CONTAINING 1, 2 or 3 HETEROATOMS SELECTED INDEPENDENTLY BETWEEN O, S and N; X ES - (CH2) m-, - (CH2) mO- (CH2) n-, - (CH2) m-NH- (CH2) n-, - (CH2) mS (O) 2- (CH2) n- , AMONG OTHERS, WHERE m AND n ARE INDEPENDENTLY 0, 1, 2, 3 or 4; Y IS O or S; R1 AND R2 ARE INDEPENDENTLY H, HALOGEN, CN, CF3, C1-6 ALKYL, OH, SO2H, NH2, NHC (O) OH, NHS (O) 2H, C3-6 CYCLOALKYL, SO2NH2, CONH2, AMONG OTHERS; R5 IS H, C1-6 ALKYL, ARYL, HETEROARYL, C3-6 CYCLOALKYL, AMONG OTHERS; AND R6 IS H, C1-6 ALKYL, C1-6 ALKYLARIL, C1-6 ALKYLHETEROARYL, AMONG OTHERS. THE COMPOUNDS OF FORMULA I ARE ANTAGONISTS OF PPAR-ALPHA AND THEREFORE, USEFUL IN THE TREATMENT OF CANCERS OF PROSTATE, BREAST, COLON, PANCREAS, CHRONIC HUMAN LYMPHOCYTIC LEUKEMIA, MELANOMA, AMONG OTHERS. IT ALSO REFERS TO PHARMACEUTICAL COMPOSITIONS THAT INCLUDE A COMPOUND OF FORMULA I OR ONE OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS. THE PRODUCTS OF THE INVENTION ARE ALSO USEFUL IN THE TREATMENT OF VIRAL INFECTIONS, SUCH AS INFECTIONS BY HCV OR HIV |