| abstract |
REFERS TO TRICYCLIC COMPOUNDS OF FORMULA (I) WHERE R1, R2, R3, R4, X, Z AND n ARE AS DEFINED IN THE DESCRIPTION. PREFERRED COMPOUNDS ARE: 1,3-DIMETHYL-10- (5-METHYLFURAN-2-IL) -5-PHENYL-7,8-DIHYDRO-1H-PYRIMID [4 ', 5': 3,4] PIRROLO [2, 1-c] [1,4] THIAZINE-2,4 (3H, 10H) -DIONA; 1,3-DIMETHYL-10- (4-METHYLTHIAZOL-2-IL) -5-PHENYL-7,8-DIHYDRO-1H-PYRIMID [4 ', 5': 3,4] PYRROLO [2,1-c] [1,4] THIAZINE-2,4 (3H, 10H) -DIONA; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THESE COMPOUNDS ARE INHIBITORS OF TRANSMENBRANE CONDUCTANCE REGULATORY PROTEIN IN CYST FIBROSIS (CFTR), BEING USEFUL IN THE TREATMENT OF POLYCHISTIC KIDNEY DISEASE AND DIARRHEA |