abstract |
THE INVENTION REFERS TO COMPOUNDS TARGETING A HUMAN ANDROGEN RECEPTOR (RA) TO INHIBIT THE LEVELS OF THE ANDROGEN RECEPTOR IN A CELL, FOR WHICH THEY ARE USEFUL IN THE TREATMENT OF CANCER AND AS INHIBITORS OF THE GROWTH OR CANCER PROLIFERATION. THE COMPOUNDS OF THE INVENTION INCLUDE A MODIFIED OLIGONUCLEOTIDE WITH A LENGTH OF 10 TO 30 UNITED NUCLEOSIDES. IT ALSO REFERS TO COMPOSITIONS THAT INCLUDE SUCH COMPOUNDS, OPTIONALLY TOGETHER WITH AN ANTIANDROGENIC AGENT, SUCH AS ABIRATERONE, AMONG OTHERS |