| abstract |
THE INVENTION REFERS TO A METHOD FOR PRODUCING, ON AN INDUSTRIAL SCALE, A CAPSULAR POLYSACARIDE OF TYPE B HAEMOPHILUS INFLUENZAE (PRP) INTENDED FOR THE PURPOSES OF VACCINATION, ACCORDING TO WHICH A STRAIN OF HAEMOPHILIBUS INFLUENZAE IS CULTIVATED IN A MEDIUM-TYPE INFLUENZAE (HAEMOPHILUS INFLUENZAE) CROP AND THE CROP SUPERNADANT IS COLLECTED AND TREATED IN ORDER TO EXTRACT THE CAPSULAR POLYSACCHARIDE FROM IT, INCLUDING SAID CULTURE MEDIUM AT LEAST: A SOURCE OF CARBON, PROTOPORPHYRIN, SALTS, AMINO ACIDES, NADIATED, NADIATED MEANS TO REGULATE PH, CHARACTERIZED BY THAT SAID GROWING MEDIA IS CHEMICALLY DEFINED. |