| abstract |
Referring to the L-malate salt of 2-amino-N - [(R) -1-benzyloxymethyl-2 - ((4S, 5R) -2-methyl-1-oxo-4-phenyl-2,7-diaza -spiro [4.5] dec-7-yl) -2-oxo-ethyl] -2-methyl-propionamide, an L-malate salt of 2-amino-N - ((2R) -3 (benzyloxy) -1- ( 2-methyl-1-oxo-4-p-tolyl-2,7-diazaspiro [4.5] decan-7-yl) -1-oxopropan-2-yl) -2-methylpropanamide, and an L-malate salt of 2-amino-N - [(R) -1-benzyloxymethyl-2 - ((4S, 5R) -4-fluoro-phenyl) -2-methyl-1-oxo-2,7-diaza-spiro [4.5] dec -7-yl] -2-oxoethyl} 2-methyl-propionamide, and with the crystalline forms thereof. It also refers to a pharmaceutical composition. Said compounds are agonists of the ghrelin receptor and are useful in the treatment of disorders and / or diseases characterized by gastrointestinal dysmotility. |