abstract |
REFERS TO COMPOUNDS DERIVED FROM QUINOLINE OF FORMULA (I) WHERE R1, R2, R3, R4, R5 AND R6 ARE EACH H, HYDROXYL, CN, ALCOXY (C1-C6), AMONG OTHERS; L IS A CONNECTOR SUCH AS -CH2-CH2- OR -CH = CH-; HET IS A COMPOUND OF FORMULA (i), (ii), AMONG OTHERS, OPTIONALLY SUBSTITUTED. THE PREFERRED COMPOUNDS ARE: 2 - [(E) -2- (5,8-DIMETHYL- [1,2,4] TRIAZOLO [1,5-a] PIRAZIN-2-IL) -VINYL] -6-TRIFLUOROMETHYL-QUINOLINE ; 6- [2- (5,8-DIMETHYL- [1,2,4] TRIAZOLO [1,5-a] PYRAZIN-2-IL) -ETHYL] -1,3-DIOXOLO [4,5-g] QUINOLINE ; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF THE PDE10A ENZYME, BEING USEFUL IN THE TREATMENT OF PSYCHIATRIC OR NEURODEGENERATIVE DISORDERS |