| abstract |
REFERS TO A COMPOUND OF FORMULA I, WHERE: U IS CH2 OR CHR2; V IS CH2, CHR2, OR CO; W IS NR1 OR CR3R6; R1 IS AR, HET, COA, AMONG OTHERS; R2 IS A, AR1, HAL, CN, AMONG OTHERS; R3 IS H, OH, AMONG OTHERS; R6 IS A OR AR1; AR IS PHENYLUS, HAL, A, AMONG OTHERS; AR1 IS PHENYL, HAL, A, (CH2) MOH, AMONG OTHERS; HET IS HETEROCICLIC OPTIONALLY SUBSTITUTED WITH 1 TO 4 ATOMS OF N, O AND / OR S; A IS C1-C10 ALKYL; HAL IS F, CL, BR O I; M IS 0-4. PREFERRED COMPOUNDS ARE: 2- [4- (4-METHOXY-PHENYL) -PIPERAZIN-1-IL] 5,6,7,8-TETRAHYDRO-3H-QUINAZOLIN-4-ONA; 2- [4- (3-FLUOROPHENYL) PIPERAZIN-1-IL] -5,6,7,8-TETRAHYDRO-3H-QUINAZOLIN-4-ONA; AMONG OTHERS. SAID COMPOUND IS AN INHIBITOR OF TANKIRASE, USEFUL IN THE TREATMENT OF CANCER. |