| abstract |
REFERS TO BENZYL SULFONAMIDE DERIVATIVE COMPOUNDS OF FORMULA (I) WHERE R1 IS -CH3 OR -CF3; R2 IS H, -CH3, -CH2OCH3 OR -CH2OCH2CH3; R3 IS H, (C1-C2) ALKYL, -CH2OCH3 OR -CH2OCH2CH3; R4 IS H, HALO OR -OCH3; R5 IS H OR HALO; A IS CH, C-F, C-CN O N; X IS CH, CF, C-OCH3 OR N. THE PREFERRED COMPOUNDS ARE: N - [(1S) -2,2,2-TRIFLUORO-1- {4 - [({(2S) -2 - [(5 -FLUOROPYRIDIN-2-IL) OXY] -3-METOXYPROPYL} AMINO) METHYL] PHENYL} ETHYL] METANSULFONAMIDE; N - {(1R) -1- [4 - ({[(2R) -2- (PYRIDIN-2-ILOXI) PROPYL] AMINO} METHYL) PHENYL] ETHYL} METANSULFONAMIDE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE INHIBITORS OF THE MOGAT-2 RECEPTOR (MONACILGLICEROL ACILTRANSFERASE-2) AND ARE USEFUL IN THE TREATMENT OF HYPERTRIGLYCERIDEMIA |