| abstract |
IT REFERS TO A PROLONGED-RELEASE PHARMACEUTICAL FORMULATION, INCLUDING: a) 40-O- (2-HYDROXY) ETHYL-RAPAMYCIN; AND b) A PROLONGED RELEASE COATING INCLUDING: i) A WATER-INSOLUBLE COATING FORMER POLYMER, SUCH AS POLYMETHACRYLATES, POLYVINYLACETATE, AMONG OTHERS; AND ii) A PORE FORMER SUCH AS POLYETHYLENE GLYCOL, POLOXAMERO 188, POVIDONE, AMONG OTHERS; AND A PROTECTIVE LAYER, WHERE THE PROTECTIVE LAYER SEPARATES THE LAYER INCLUDING 40-O- (2-HYDROXY) ETHYL-RAPAMYCIN FROM THE PROLONGED RELEASE LAYER; IN ADDITION, SUCH FORMULATION INCLUDES A BINDER, A FILLER, A DISINTEGRANT, A LUBRICANT OR A DESICCANT. IT ALSO REFERS TO A PROCESS FOR THE MANUFACTURE OF SAID PHARMACEUTICAL FORMULATION. SUCH COMPOSITION IS USEFUL FOR THE TREATMENT OF ARTHRITIS, LUPUS ERYTHEMATOSUS, ULCEROUS COLITIS, PSORIASIS, MULTIPLE SCLEROSIS |