| abstract |
IT REFERS TO A PROCESS TO PRODUCE GADOBUTROL INCLUDING: REACTING CYCLENE (1,4,7,10-TETRAAZACICLODODECANE) WITH 4,4-DIMETHYL-3,5,8-TRIOXABICYCLE [5.1.0] OCTANE AND LITHIUM CHLORIDE IN ALCOHOL AT HIGH TEMPERATURES, RENT WITH SODIUM MONOCLOROACETATE IN ALKALINE MEDIUM, CONTINUING THE WORK UNDER ACID CONDITIONS, THEN REMOVE THE SALTS AND ADD GADOLINIUM OXIDE, ADJUST THE pH WITH LITHIUM HYDROXIDE NEUTRAL HYDROXIDE, SOLID HYDROXIDE, LITHIUM HYDROXIDE ADD ALCOHOL, HEAT UNDER REFLUX AND, AFTER COOLING, ISOLATING AND DRYING THE CRUDE PRODUCT, DISSOLVE THE CRUDE PRODUCT IN WATER AND PURIFY WITH A CASCADE OF ION EXCHANGERS, THEN TREAT WITH ACTIVATED CARBON FOLLOWED BY STERILE LIFETIME FILTRATION REFLOW, COOL AND ISOLATE THE PRODUCT |