| abstract |
REFERS TO INHIBITING COMPOUNDS OF DIACILGLICEROL ACILTRANSFERASE OF FORMULA (I) WHERE R1 IS A BICYCLE RING SYSTEM CONSISTING 9 TO 11 MEMBERS OF THE RING INCLUDING 1 TO 4 HETEROATOMS, AMONG OTHERS; R2 AND R3 IS INDEPENDENTLY H, C1-C6 ALKYL, HALO, HYDROXYL, AMONG OTHERS; m IS 0-2. PREFERRED COMPOUNDS ARE THE ACID 2- (6- {4-AMINO-5-OXO-5H, 6H, 7H, 8H-PYRIMIDO [5,4-F] [1,4] OXAZEPIN-6-IL} -1-OXO -1,2,3,4-TETRAHYDROISOQUINOLIN-2-IL) ACETIC, 2- (6- {4-AMINO-5-OXO-5H, 6H, 7H, 8H-PYRIMIDO [5,4-F] [1, 4] OXAZEPIN-6-IL} -2-OXO-1,2,3,4- TETRAHYDROISOQUINOLIN-1-IL) ETHYL ACETATE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION THAT IS USEFUL FOR THE TREATMENT OF OBESITY-RELATED DISORDERS |