| abstract |
REFERS TO COMPOUNDS DERIVED FROM INDAZOLES OF FORMULA (I) WHERE R1 IS HALO; R2 IS ALKYL (C1-C6) OPTIONALLY SUBSTITUTED WITH FLUORINE; X IS A LINK, -CO-, -SO2- OR -CH2-; R3 IS ARIL1, HET1, AMONG OTHERS, WHERE ARIL1 IS PHENYL OR NAFTHYL; HET1 IS AN AROMATIC HETEROCYCLE OF 5 OR 6 MEMBERS; n IS 1 OR 2. PREFERRED COMPOUNDS ARE: {2- [6- (2-ETHYL-5-FLUORO-4-HYDROXY-PHENYL) -1H-INDAZOL-3-IL] -1,4,6,7-TETRAHYDRO -IMIDAZO [4,5-c] PYRIDIN-5-IL} - (4-FLUORO-PHENYL) -METHANONE; {2- [6- (2-ETHYL-5-FLUORO-4-HYDROXY-PHENYL) -1H-INDAZOL-3-IL] -1,4,6,7-TETRAHYDRO-IMIDAZO [4,5-c] PYRIDIN -5-IL} -ISOTHIAZOL-3-IL-METHANONE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE INHIBITORS OF JANUS KINASE (JAK) BEING USEFUL IN THE TREATMENT OF ASTHMA, ALLERGIC RHINITIS, CHRONIC BRONCHITIS |