| abstract |
REFERS TO PYRAZOLE COMPOUNDS OF FORMULA (Ia) OR (Ib) WHERE: Ra AND Rb ARE INDEPENDENTLY H, HYDROXY, ALCOXI C1-C6, AMONG OTHERS, OR Ra AND Rb TOGETHER WITH THE CARBON ATOM TO WHICH THEY ARE UNITED FORM A CARBONYL GROUP; Rc AND Rd ARE INDEPENDENTLY H, HALOGEN, C1-6 HALOALKYL, AMONG OTHERS OR Rc AND Rd TOGETHER WITH THE CARBON ATOM TO WHICH THEY ARE UNITED FORM A CARBONYL GROUP, AMONG OTHERS; Y1, Y2, Y3, Y4 AND Y5 ARE INDEPENDENTLY N AND CRY, WHERE RY IS H, HYDROXY, CYANO, AMONG OTHERS; Z IS O, S, AND NRZ, WHERE RZ IS H, C1-C6 ALKYL OR BENZYL; R1 AND R2 IS INDEPENDENTLY H, PHENYL, NAPHTHYL, AMONG OTHERS; n IS AN INTEGER NUMBER BETWEEN 0 TO 3; R3 IF IT IS PRESENT, IT IS HALOGEN, C1-C6 ALKYL, C1-C6 ALCOXY, AMONG OTHERS. PREFERRED COMPOUNDS ARE: (1- (2-FLUORO-4 - [(1H-INDOL-2-CARBONYL) AMINO] BENZYL) -3,5-DIMETHYL-1H-PYRAZOLE-4-IL) ACETIC ACID; (1- {4 - [(5-FLUORO-3-METHYLBENZOFURAN-2-CARBONYL) AMINO] BENZYL} -3,5-DIMETHYL-1H-PIRAZOL-4-IL) ACETIC ACID; AMONG OTHERS. ALSO REFERRED TO PHARMACEUTICAL FORMULATIONS THAT CONTAIN SUCH COMPOUNDS IN COMBINATION WITH ONE OR MORE ACTIVE SUBSTANCES SUCH AS BETAMIMETICS, ANTICHOLINERGICS, CORTICOSTEROIDS, AMONG OTHERS |