| abstract |
REFERS TO A PEPTIDE DERIVED FROM OXINTOMODULIN THAT ACTIVATES THE GLP-1 RECEPTOR AND THE GLUCAGON RECEPTOR THAT INCLUDES THE SEQUENCE OF AMINO ACIDS OF FORMULA 1 WHICH IS R1-X1-X2-GTFTSD-X3-X4-X5-X6-X7- X8-X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-X19-X20-X21-X22-X23-X24-R2, WHERE R1 IS HISTIDINE, DESAMINOHYSTIDILO, 4-IMIDAZOACETILO, AMONG OTHERS; X1 IS AMINOISOBUTYRIC ACID, GLYCINE, AMONG OTHERS; X2 IS GLUTAMIC ACID OR GLUTAMINE; X3 IS LEUCINE OR TYROSINE; X4 IS SERINE OR ALANINE; X5 IS LYSINE OR ARGININE; X6 IS GLUTAMINE OR TYROSINE; X7 IS LEUCINE OR METHIONINE; X8 IS ASPARTIC OR GLUTAMIC ACID; X9 IS SERINE, AMONG OTHERS; X10 IS GLUTAMINE, LYSINE, AMONG OTHERS; X11 IS ALANINA, VALINA, AMONG OTHERS; X12 IS SERINA, VALINA, AMONG OTHERS; X13 IS LYSINE, GLUTAMINE, AMONG OTHERS; X14 IS ASPARTIC ACID, LEUCINE, AMONG OTHERS; X15 IS PHENYLALANINE; X16 IS ISOLEUCIN, AMONG OTHERS; X17 IS ALANINE, CYSTEINE, AMONG OTHERS; X18 IS TRYPTOPHAN; X19 IS ISOLEUCINE, SERINE, AMONG OTHERS; X20 IS LYSINE, METHIONINE, AMONG OTHERS; X21 IS ASPARAGINE; X22 IS ALANINE, TREONINE, AMONG OTHERS; X23 IS CYSTEINE, AMONG OTHERS; X24 IS A PEPTIDE OF 2 TO 10 AMINO ACIDS; R2 IS SEQ ID NO: 32, 33, 34, 35, 36, 37 OR IT IS DELETED. ALSO REFERS TO A USEFUL PHARMACEUTICAL COMPOSITION IN THE TREATMENT OF OBESITY |