| abstract |
REFERRED TO A PHARMACEUTICAL COMPOSITION, INCLUDING: a) A COMPOUND OF FORMULA (I) SUCH AS ACID (4- {4- [5- (6-TRIFLUORO-METHYL-PYRIDIN-3-IL-AMINO) -PYRIDIN-2 -IL] -PHENYL} -CYCLOHEXIL) -ACETIC OR A SALT OF THE SAME, b) ONE OR MORE TENSOACTIVES WITH LUBRICATING PROPERTIES SUCH AS SODIUM LAURYL-SULFATE, STEARIC ACID, PALMTITIC ACID, AMONG OTHERS, IN AN AMOUNT OF 0.1% 5% BY WEIGHT OF THE COMPOSITION, c) ONE OR MORE DRY BINDERS WITH DISINTEGRANT PROPERTIES SUCH AS POLYETHYLENE GLYCOLS, PREGELATINIZED STARCH, CHITOSANE, STARCH, AMONG OTHERS, IN AN AMOUNT OF 5% TO 15% BY WEIGHT COMPOSITION d) OR MORE FILLERS SUCH AS A MIXTURE OF MICROCRYSTALINE CELLULOSE AND ANHYDROUS LACTOSE, WHERE THE RATIO OF MICROCRIATALINE CELLULOSE TO LACTOSE IS BETWEEN 1: 5 AND 1: 1, e) ONE OR MORE DISINTEGRANTS SUCH AS CROSYCYCARDULONE-REHYDOLYLIDE CROSSYLODYLIDE GLASS OF SODIUM STARCH. IT ALSO REFERS TO A PREPARATION PROCESS THAT INCLUDES THE STEPS OF: MIXING THE FORMULA COMPOUND (I) WITH AN EXCIPIENT, COMPACTING WITH A ROLLER, GRINDING THE MIXTURE, LUBRICATING THE RESULTING MIXTURE AND COMPRESSING THE MIXTURE OF SOLID FORM |