| abstract |
REFERS TO COMPOUNDS DERIVED FROM PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE SUBSTITUTED WITH CYCLOBUTYL OF FORMULA (I) WHERE X AND W ARE EACH CH O N; Y IS H, CN, ALKYL (C1-C3), AMONG OTHERS; L IS O, S, C (= O), C (= O) O, AMONG OTHERS; Z IS CR4 O N; R1, R2, R3 AND R4 ARE EACH H, HYDROXY, HALO, ALKYL (C1-C3), AMONG OTHERS; R5 IS HYDROXY, ALCOXY (C1-C4), F, ALKYL (C1-C4), AMONG OTHERS; A IS H, ALKYL (C1-C6), CYCLALKYL (C3-C10), ARYL (C6-C10), AMONG OTHERS; m IS 0 TO 2; n IS FROM 0 TO 4. THE PREFERRED COMPOUNDS ARE: 3 - [(4- {3- (CYANOMETHYL) -3- [4- (7H-PYRROLO [2,3-d] PYRIMIDIN-4-IL) -1H-PIRAZOLE -1-IL] CYCLOBUTYL} PIPERAZIN-1-IL) METHYL] -5-FLUOROBENZONITRILE; 3 - [(4- {3- (CYANOMETHYL) -3- [4- (7H-PYRROLO [2,3-d] PYRIMIDIN-4-IL) -1H-PYRAZOL-1-IL] CYCLOBUTIL} PIPERAZIN-1- IL) METHYL] -6- (DIMETHYLAMINE) -2-FLUOROBENZONITRILE; 4- {3- (CYANOMETHYL) -3- [4- (7H-PYRROLO [2,3-d] PYRIMIDIN-4-IL) -1H-PIRAZOL-1-IL] CYCLOBUTIL} -N- [4-FLUORO- 2- (TRIFLUOROMETHYL) PHENYL] PIPERAZIN-1-CARBOXAMIDE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE INHIBITORS OF JANUS KINASES (JAK) BEING USEFUL IN THE TREATMENT OF MULTIPLE SCLEROSIS, RHEUMATOID ARTHRITIS, CANCER, MYELOPHIBROSIS |