abstract |
REFERRING TO A PIPERIDINE DERIVED COMPOUND OF FORMULA (I '), WHERE R2 IS HALOGEN; a ES 0, 1 O 2; b IS 0 O 1; R5 IS H, OH, C1-C3 ALKYL, C (HALO) 3, HALOGEN; R1 IS CYCLOALKYL (C9-C14) OR Bicycloalkyl (C9-C14) SUBSTITUTED WITH R3; R3 IS C1-C4 ALKYL, C2-C6 ALKENYL, C2-C6 ALKINYL, OR C3-C6 CYCLOALKYL. THE PREFERRED COMPOUNDS ARE: (a), (b), (c), AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS MODULATE THE FUNCTION OF THE ORL-1 RECEPTOR AND ARE USEFUL IN THE TREATMENT OF PAIN, DEPRESSION, DEMENTIA, ANXIETY, AMONG OTHERS |