Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6572ff5df928fd17340eb2a8cb6d8502 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-10 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 |
filingDate |
2012-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7347909417d750a3fa52ee8724d0f4b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebe69a5554d372be48fc983b794aafc9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26195b51f6283ae4140556682683a155 |
publicationDate |
2014-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
PE-20140037-A1 |
titleOfInvention |
NEW PROCEDURE FOR THE SYNTHESIS OF AGOMELATIN |
abstract |
IT REFERS TO A PROCEDURE FOR THE SYNTHESIS OF AGOMELATIN THAT INCLUDES: A) REACTING THE ALYL CYANIDE (CH2 = CHCH2CN) WITH A COMPOUND OF FORMULA (III) TO OBTAIN A COMPOUND OF FORMULA (IV) IN THE PRESENCE OF CHLOROBENENX IS SC (S) -OR, WHERE R IS ALKYL (C1-C6); B) SUBMIT THE FORMULA COMPOUND (IV) TO A CYCLING REACTION AT A TEMPERATURE OF 130 TO 135�C IN THE PRESENCE OF A RADICAL PRIMER TO FORM THE FORMULA COMPOUND (V); C) SUBMIT THE COMPOUND (V) TO A REDUCTION OR DEHYDRATION REACTION TO FORM THE FORMULA COMPOUND (VI) IN THE PRESENCE OF ALUMINUM ISOPROPOXIDE; D) SAID COMPOUND (VI) IS SUBMITTED TO AN AROMATIZATION REACTION TO FORM THE FORMULA COMPOUND (VII) IN THE PRESENCE OF A QUINONE; E) SUBMIT THE COMPOUND (VII) TO A REDUCTION BY HYDROGEN IN THE PRESENCE OF RANEY NICKEL IN A POLAR PROTIC MEDIUM AND TO A REACTION WITH ACETIC ANHYDRIDE TO OBTAIN AGOMELATIN, WHICH IS ISOLATED IN THE FORM OF A SOLID |
priorityDate |
2011-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |