abstract |
REFERS TO HETEROCICLIC COMPOUNDS OF FORMULA (I) WHERE: RING A IS OXAZOLE, TRIAZOLE, IMIDAZOLE, AMONG OTHERS OPTIONALLY SUBSTITUTED; RING B IS AN OPTIONALLY REPLACED BENZENE, PYRIDINE OR PYRIMIDINE RING; THE PARTIAL STRUCTURE (1) IS a) OR b), R1 AND R2 ARE THE SAME OR DIFFERENT AND EACH ONE IS A SUBSTITUTE; WHERE R1 IS HYDROXY, ALCOXY (C1-C6), CARBOXY, AMONG OTHERS; R2 IS HALOGEN, A HETEROCYCLIC GROUP, AMONG OTHERS; R3 IS A SUBSTITUTE; n IS AN INTEGER FROM 0 TO 6; L IS O, S, SO, SO2, AMONG OTHERS. IT IS A PREFERRED COMPOUND: 2- {8- (4-CHLORO-3-FLUOROPHENOXY) -3- [3-METOXY-4- (2-METHYL-1,3-OXAZOL-5-IL) PHENYL] -5.6 , 7,8-TETRAHYDRO [1,2,4] TRIAZOLO [4,3-a] PYRIDIN-8-IL} PROPAN-2-OL; 2 - {(8R) -3- [6-METOXY-5- (4-METHYL-1H-IMIDAZOL-1-IL) PYRIDIN-2-IL] -8- (3,4,5-TRIFLUOROPHENOXY) -5, 6,7,8-TETRAHYDRO [1,2,4] TRIAZOLO [4,3-a] PYRIDIN-8-IL} PROPAN-2-OL; AMONG OTHERS. SUCH COMPOUNDS ARE USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE |