| abstract |
REFERRING TO A COMPOUND OF FORMULA (I), WHERE A1 IS N OR C (A2); A2 IS H, F, Cl, NO2, CF3, AMONG OTHERS; B1 IS H, F, Cl, Br, OH, NO2, AMONG OTHERS; D1 IS H, CN, NO2, N3, AMONG OTHERS; E1 IS H, CN, NO2, N3, OH, AMONG OTHERS; Y1 IS H, CN, NO2, C (O) OH, F, Cl, AMONG OTHERS; G1 IS H O C (O) O; Z1 IS R26 OR R27; Z2 IS R28, R29 OR R30; Z1A AND Z2A ARE CH2, CH2CH2 OR Z12A; Z12A IS C2-C6 ALKYLENE; L1 IS C (N) NH, SO2NH, AMONG OTHERS; R26 IS PHENYLENE, AMONG OTHERS; R27 IS HETEROARYLENE, AMONG OTHERS; R28 IS PHENYLENE, AMONG OTHERS; R29 IS HETEROARYLENE, AMONG OTHERS; R30 IS CYCLOALKYLENE, CYCLOALKENYLENE, AMONG OTHERS. FAVORITE COMPOUNDS ARE: 4- {4 - [(4'-CHLORO-1,1'-BIPHENYL-2-IL) METHYL] PIPERAZIN-1-IL} -N - ({3-NITRO-4 - [(TETRAHYDRO- 2H-PYRAN-4-ILMETHYL) AMINO] PHENYL} SULFONYL) -2- (1H-PYRROLO [2,3-b] PYRIDIN-5-ILOXI) BENZAMIDE, 4- {4 - [(4'-CHLORO-1, 1'-BIPHENYL-2-IL) METHYL] PIPERAZIN-1-IL} -N - ({4 - [(3-MORPHOLIN-4-ILPROPYL) AMINO] -3-NITROPHENYL} SULFONYL) -2- (1H-PIRROLO [2,3-b] PYRIDIN-5-ILOXI) BENZAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS INHIBIT THE ACTIVITY OF ANTI-APOPTOTIC PROTEINS Bcl-2 AND ARE USEFUL IN THE TREATMENT OF CANCER AND IMMUNE DISEASES |