abstract |
REFERS TO BISARYLL-LINKED ARYLTHRIAZOLONE COMPOUND OF FORMULA (I) IN WHICH R1 REPRESENTS ALKYL (C1-C6), ALKENYL (C2-C6), ALKINYL (C2-C6); AR1 REPRESENTS PHENYL, TIENYL, FURILO AMONG OTHERS; L1 IS -CH2-, -C (= O) -, -SO2-; Q IS A PHENYL RING, A 5-MEMBER HETEROARYL RING WITH 1-3 HETEROATOMS SELECTED FROM N, O, S, AMONG OTHERS; R2 IS A SELECTED SUBSTITUTE OF FLUOR, BROMINE, NITRO, CYCLOALKYL- (C3-C6), PHENYL AMONG OTHERS; n is 0-2; L2 IS A LINK, IS A GROUP OF THE FORMULA - (CR3AR3B) p-, IN WHICH R3A IS H, F, METHYL; R3B IS H, (C1-C4) ALKYL, AMONG OTHERS; Ar2 IS A PHENYL, NAPHTHYLUS, HETEROARYL OF 5- 10 MEMBERS WITH 1-3 HETEROATOMS SELECTED AMONG N, O, S, AMONG OTHERS. SOS PREFERRED COMPOUNDS: 5- (4-CHLOROPHENYL) -4-CYCLOPROPYL-2 - ({1- [2- (TRIFLUORomethyl) BENZYL] -1H-1, 2,4-TRIAZOL-5-IL.} SULFONIL) -2 , 4-DIHYDRO-3H-1, 2,4-TRIAZOL-3-ONA; 5- (4-CHLOROPHENYL) -4-CYCLOPROPYL-2 - ({1- [2,6-DICHLOROBENZYL) -1H-1, 2,4-TRIAZOL-5-IL] SULFONYL) -2,4-DIHYDRO-3H -1, 2,4-TRIAZOL-3-ONA, AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE AND A PHARMACEUTICAL COMPOSITION. SAID COMPOUND IS USEFUL IN THE TREATMENT OF HEART FAILURE, HYPONATREMIA, HEPATIC CIRRHOSIS, AMONG OTHERS. |