| abstract |
REFERS TO GLUCAGON ANALOGS OF FORMULA R1-X-Z-R2 WHERE R1 IS H, ALKYL (C1-C4), ACETYL, FORMYL, AMONG OTHERS; R2 IS OH OR NH2; X IS A PEPTIDE OF FORMULA His-X2-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-X16-X17-Arg-Ala-X20-Asp-Phe- Ile-Glu-Trp-Leu-X27-X28-X29 WHERE X2 IS Ser Y Aib; X16 IS Glu E Y; X17 IS Arg E Y; X20 IS Lys E Y; X27 IS Leu E Y; X28 IS ABSENT OR IS Ser E Y; X29 IS ABSENT OR IS Ala; AND IS Lys, Cys O Orn; Z IS ABSENT OR IS A SEQUENCE OF 1 TO 20 UNITS OF AMINO ACIDS SUCH AS Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, Dpr AND Orn; WHERE THE LATERAL CHAIN OF AN AMINO ACID AND X RESIDUE IS CONJUGATED WITH A LIPOFIL SUBSTITUTE. ALSO REFERS TO A PHARMACEUTICAL COMPOSITION THAT IS USEFUL IN THE TREATMENT OF OBESITY, HYPERTENSION, ATHEROSCLEROSIS, CORONARY CARDIOPATHY |