| abstract |
REFERS TO A COMPOUND OF FORMULA (I) WHERE: X IS NRa, O, S (O) r; Ra IS H OR ALKYL 1-6; r IS AN INTEGER FROM 0 TO 2; m IS AN INTEGER FROM 0 TO 3; R1 IS C1-6 ALKYL, C2-6 ALKYLYL, C2-6 ALKYL, AMONG OTHERS; R2 IS HALOGEN, C1-6 ALCOXY, CYANE, C1-6 HALO-ALKYL, AMONG OTHERS; R3 IS HALOGEN, CYANE, C1-6 ALKYL, C1-6 HALO-ALKYL, AMONG OTHERS; R5 IS H OR C1-6 ALKYL; n IS 0 O 1; R6 IS H, C1-6 ALKYL, C1-6 AMINO-ALKYL, AMONG OTHERS; OR R5 AND R6 TOGETHER WITH THE NITROGEN ATOM FORM A RING OF 3 TO 7 LINKS; R7 IS HALOGEN, C1-6 ALKYL, C1-6 ALCOXY, C1-6 HALO-ALKYL OR C1-6 HALO-ALCOXY. THE PREFERRED COMPOUND is 5-CHLORO-4- (5-CHLORO-4-METHYLAMINE-PYRIMIDIN-2-ILAMINE) -2-METHOXY-BENZAMIDE; AMONG OTHERS. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUND IS A MODULATOR OF KINASE ACTIVITY WITH REPETITIONS RICH IN LEUCINE 2 (LRRK2), BEING USEFUL FOR THE TREATMENT OF PARKINSON'S DISEASE |