abstract |
REFERS TO COMPOUNDS OF FORMULA I WHERE: U ES = N- O = C (R5), V ES -CH = O -N =, W ES = CH O = N-, WITH THE CONDITION THAT ONLY ONE CAN BE N ; R5 IS H, METHYL OR HALOGEN; Y IS -O-, -CH2O-, -CH2S (O) 2, AMONG OTHERS; R1 IS PHENYL OR HETEROARYL OPTIONALLY SUBSTITUTED BY HALOGEN, LOWER ALKYL AND LOWER ALCOXY; R2 / R2´ TOGETHER WITH THE CARBON ATOM TO WHICH THEY ARE UNITED, FORM C3-C6 CYCLOALKYL OR A RING CONTAINING -CH2OCH2-, OR ARE INDEPENDENTLY H, LOWER ALKYL, HYDROXY, LOWER ALCOXY, AMONG OTHERS; m IS 0, 1, O 2; WHEN m IS 1: R3 / R3´ TOGETHER WITH THE CARBON ATOM TO WHICH THEY ARE BINDED, FORM C3-C6 CYCLOALKYL, OR ARE INDEPENDENTLY H, LOWER ALKYL, LOWER CH2-ALCOXY; n IS 0 O 1; WHEN n IS 1: R4 / R4´ TOGETHER WITH THE CARBON ATOM TO WHICH THEY ARE BINDED, THEY FORM C3-C6 CYCLOALKYL, OR ARE INDEPENDENTLY H, LOWER ALKYL, LOWER CH2-ALCOXY. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION AND A PROCEDURE FOR OBTAINING. SAID COMPOUNDS ARE MGLUR5 ALOSTERIC MODULATORS, BEING USEFUL FOR THE TREATMENT OF SCHIZOPHRENIA, AUTISM |