abstract |
REFERRING TO A QUINOLINE DERIVED COMPOUND OF FORMULA (I), WHERE X1 IS N OR N-O; X2-X3 IS -CH2-CH2-, -O-CH2, -CH2-O- O CH2; X4, X5, X6 AND X7 ARE N, N-O, CH, O; R1 IS H, HALOGEN, C1-C6 ALKYL, AMONG OTHERS; R2A AND R2B ARE H, OH, HALOGEN, TOGETHER FORM = O; R3 IS HALOGEN, C1-C6 O-ALKYL, C1-C6 S-ALKYL, AMONG OTHERS; R4 IS OH, HALOGEN, C1-C6 ALKYL, C1-C6 O-ALKYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 4 - [(6-CHLOROPYRIDIN-3-IL) METHYL] -N - [(1S, 2S) -2-HYDROXICICLOHEXYL] QUINOLINE-2-CARBOXAMIDE, N - [(1S, 2S) -2-HYDROXICICLOHEXIL ] -4 - [(6-METHYLPYRIDIN-3-IL) METHYL] QUINOLINE-2-CARBOXAMIDE, N - [(1S, 2S) -2-HYDROXICICLOHEXYL] -4- (PYRIDIN-3-ILMETHYL) QUINOLINE-2-CARBOXAMIDE , AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE POSITIVE ALLOSTERIC MODULATORS OF M1 RECEPTORS AND ARE USEFUL IN THE TREATMENT OF DISORDERS SUCH AS ALZHEIMER'S DISEASE, SCHIZOPHRENIA, PAIN OR SLEEP DISORDERS |