| abstract |
REFERRING TO A BENZOXEPINE DERIVATIVE COMPOUND OF FORMULA (I), WHERE Z1 IS CR1 O N; Z2 IS CR2 O N; Z3 IS CR3 O N; Z4 IS CR4 O N; X1 AND X2 ARE N, O, S, C (R7) 2 OR CR7; R1 IS H, HALOGEN, CN, CF3, NO2 OR C1-C4 ALKYL; R2, R3, R4 AND R7 ARE H, HALOGEN, CN, NO2, AMONG OTHERS; A IS ARYL C6-C20, HETEROARYL C1-C20, AMONG OTHERS. PREFERRED COMPOUNDS ARE: ((R) -2-HYDROXIMETHYL-PYRROLIDIN-1-IL) - [8- (1H-PYRAZOLE-4-IL) -4,5-DIHYDRO-6-OXA-3-TIA-1-AZA -BENZO [e] AZULEN-2-IL] -METHANONE, ISOPROPYL-METHYL-AMIDE OF ACID 8- (1H-PIRAZOL-4-IL) -4,5-DIHYDRO-6-OXA-3-TIA-1-AZA -BENZO [e] AZULENE-2-CARBOXYL, 2- {4- [2- (2-ISOPROPYL-2H- [1,2,4] TRIAZOL-3-IL) -4,5-DIHYDRO-6-OXA- 3-TIA-1-AZA-BENZO- [e] AZULEN-8-IL] -PIRAZOL-1-IL} -ETHANOL, 8- [1- (2-MORFOLIN-4-IL-ETIL) -1H-PIRAZOL- 4-IL] -2- [2- (2,2,2-TRIFLUOR-ETHYL) -2H- [1,2,4] -TRIAZOL-3-IL] -4,5-DIHYDRO-6-OXA-3 -TIA-1-AZA-BENZO [e] BLUE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS HAVE INHIBITING ACTIVITY OF PHOSPHATIDYLINOSITOL KINASE 3 (PI3) AND ARE USEFUL IN THE TREATMENT OF CANCER |