abstract |
REFERS TO AMINOALKYLPYRIMIDINE DERIVATIVE COMPOUNDS OF FORMULA (I) WHERE R1 IS H OR ALKYL (C1-C4); R2 IS ACETIDINYL, PYRROLIDINYL, PIPERIDINYL OR ACEPANYL OPTIONALLY SUBSTITUTED WITH ALKYL (C1-C4); OR R1 AND R2 TOGETHER WITH THE N ATOM TO WHICH THEY ARE UNITED, FORM A HETEROCICLIC MONOCYCLIC GROUP OF 4 TO 7 MEMBERS, BRIDGED BICYCLES OF 7 TO 8 MEMBERS OR FUSED BICYCLES OF 8 TO 12 MEMBERS OPTIONALLY SUBSTITUTED; R3 IS H O ALKYL (C1-C8); R4 IS ALKYL (C1-C8) OPTIONALLY SUBSTITUTED WITH HALOGEN, CYCLOALKYL (C3-C10) -ALKYL (C0-C4), ARYLALKYL (C0-C4), AMONG OTHERS; R5 IS H O ALKYL (C1-C8); n IS 1 OR 2. PREFERRED COMPOUNDS ARE: 4 - ((CYCLOPROPYLMETILAMINO) -METIL) -6- (3- (METTILAMINO) ACETTIDIN-1-IL) PIRIMIDIN-2-AMINE; 4 - ((2-ADAMANTHYLAMINE) METHYL) -6- (3- (METHYLAMINE) ACETIDIN-1-IL) PYRIMIDIN-2-AMINE; 4 - (((2,2-DIETHYL CYCLOPROPYL) -MEthylamine) METHYL) -6- (3- (METHYLAMINE) ACETIDIN-1-IL) PYRIMIDIN-2-AMINE; AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE ANTAGONISTS OF THE HISTAMINE H4 RECEPTOR, BEING USEFUL IN THE TREATMENT OF ASTHMA, ALLERGIC RHINITIS, DERMATITIS, PSORIASIS, LUPUS CUTANEUS |