| abstract |
REFERRING TO A 4-AMINOCICLOHEXAN DERIVATIVE OF FORMULA (1), WHERE Y1, Y1 ', Y2, Y2', Y3, Y3 ', Y4 AND Y4' ARE H, F, Cl, Br, NO2, CN, AMONG OTHERS; R1 AND R2 ARE H, R0 OR TOGETHER FORM -CH2CH2OCH2CH2-, -CH2CH2NR4CH2CH2- O - (CH2) 3-6; R0 IS AN ALIPHATIC GROUP C1-C8, ARYL, HETEROARYL, AMONG OTHERS; R3 IS R0; R4 IS H, R0, C (= O) R0; n IS AN INTEGER FROM 0 TO 12; X IS O, S, NRA; RA IS H, R0, C (= O) R0, C (= O) NH2, AMONG OTHERS; RB IS H, R0, C (= O) H, C (= O) OH, AMONG OTHERS; Q IS R0, C (= O) R0, C (= O) OR0, AMONG OTHERS. THE PREFERRED COMPOUNDS ARE: 1- (IMINO (1-METHYL-1H-INDOL-2-IL) METHYL) -N1, N1, N4, N4-TETRAMETHYL-4-PHENYL CYCLOHEXANE-1,4-DIAMINE, BIS (2-HYDROXYPROPANE- 1,2,3-TRICARBOXYLATE), 4- (DIMETHYLAMINE) -4-PHENYL-1- (PYRROLIDIN-1-IL) CYCLOHEXIL) - (1-METHYL-1H-INDOL-2-IL) METHANONE, 1,4- BIS (DIMETHYLAMINE) -4-PHENYL CYCLOHEXIL) (1-METHYL-1H-INDOL-2-IL) METHANONE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS HAVE AFFINITY FOR THE OPIOID MU RECEPTOR AND THE ORL-1 RECEPTOR AND ARE USEFUL IN THE TREATMENT OF PAIN |