| abstract |
REFERRING TO A COMPOUND OF FORMULA I, WHERE X IS N, CH; R1 IS C1-C3 ALKYL FLUORATED, OPTIONALLY FLUORATED C1-C4 ALCOXY, METOXY- (C2-C4 ALCOXY) PYRROLYL, AMONG OTHERS; R2 IS H, METHYL, AMINO, FLUORINE. THE PREFERRED COMPOUNDS ARE: 4- (3 - {[6- (1H-IMIDAZOL-1-IL) PYRIDIN-3-IL] METHYL} -4,4-DIMETHYL-5-OXO-2-THIOXOIMIDAZOLIDIN-1-IL) - 2- (TRIFLUOROMETHYL) BENZONITRILE; 4- (4,4-DIMETHYL-3 - {[2-METHYL-6- (TRIFLUORomethyl) PYRIDIN-3-IL] METHYL} -5-OXO-2-THIOXOIMIDAZOLIDIN-1-IL) -2- (TRIFLUORomethyl) BENZONITRILE ; 4- (4,4-DIMETHYL-5-OXO-3 - {[6- (2-OXOIMIDAZOLIDIN-1-IL) PYRIDIN-3-IL] METHYL} -2-THIOXOIMIDAZOLIDIN-1-IL) -2- (TRIFLUOROMETIL ) BENZONITRILE; AMONG OTHERS. SUCH COMPOUNDS ARE USEFUL IN THE TREATMENT OF CANCER |