abstract |
REFERRED TO A COMPOUND OF FORMULA I, WHERE X IS O, S, N; W1 IS N, C = O, NH, AMONG OTHERS; W2 IS N, CH2, C = O, AMONG OTHERS; W3 IS N, NH, N- (C1-C6 ALKYL), AMONG OTHERS; W4 IS N, C = O, CR6, AMONG OTHERS; WHERE NO MORE THAN TWO ATOMS OF N AND NO MORE THAN TWO C = O GROUPS ARE ADJACENT; W5 ES N, CR7; W6 ES N, CR8; R1 AND R2 ARE EACH H, ALKYL, HETEROALKYL, ALKENYL, CYCLOALKYL, HETEROARYL, AMONG OTHERS; R6, R7 AND R8 ARE EACH H, ALKYL, HETEROALKYL, ALKENYL, CYCLOALKYL, ARYL, ARYLALKYL, ALCOXY, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 5- (3- (PYRIDIN-4-IL) IMIDAZO [1,2-a] PYRIDIN-6-IL) BENZO [d] OXAZOL-2-AMINE; 2- (4- (8- (2-AMINOBENZO [d] OXAZOL-5-IL) -3-METHYL-2-OXO-2,3-DIHYDRO-1H-IMIDAZO [4,5-c] QUINOLIN-1- IL) PHENYL) -2-METHYLPROPANONITRILE; AMONG OTHERS. SAID COMPOUNDS ARE INHIBITORS OF PHOSPHATIDYL INOSITOL-3 KINASE (PI3 KINASE) USEFUL IN THE TREATMENT OF ASTHMA, EMPHYSEMA, PSORIASIS, ALLERGY, ANAPHYLAXIS, RESTENOSIS, DIABETES, AMONG OTHERS |