| abstract |
REFERRING TO A COMPOUND OF FORMULA I, WHERE W IS PHENYL-PYRROLIDINYL-METHANONE, 2- (ISOPROPYLSULFONIL) -PHENYL, N, N-DIMETHYLBENZENOSULFONAMIDE, 2- (1-PYRROLIDINYLSULPHONYL) PHENYL, BETWEEN OTHERS; R1 AND R2 TOGETHER FORM AN OPTIONALLY SUBSTITUTE RING OF 5-6 MEMBERS, HETEROARYL, HETERO CYCLE INCLUDING 1-3 N HETEROATOMES; R3 IS CYANE, CO2NH2, AMONG OTHERS; R4 IS H; R5 AND R5 'ARE EACH H, C1-C6 ALKYL; n IS 0. THE PREFERRED COMPOUNDS ARE: N2- (2-ISOPROPOXY-5-METHYL-4- (PIPERIDI-4-NIL) PHENYL) -N4- (2- (METHYLSULFONIL) PHENYL) -7H-PIRROLO [2,3- d] PYRIMIDINE-2,4-DIAMINE; 2- (4- (5-ISOPROPOXI-4- (4- (2- (ISOPROPYLSULFONIL) PHENYLAMINE) -7H-PYRROLO [2,3-d] PYRIMIDI-2-NILAMINO) -2-METHYLPHENYL) PIPERIDI-1-NIL ) ACETAMIDE; AMONG OTHERS. SAID COMPOUNDS ARE INHIBITORS OF PROTEIN KINASE, USEFUL IN THE TREATMENT OF PROLIFERATIVE CELLULAR DISORDERS |