| abstract |
REFERRING TO A PROCESS FOR THE PREPARATION OF A CRYSTALLINE FORM OF 3- [5- (2-FLUOROPHENIL) - [1,2,4] OXADIAZOL-3-IL] -BENZOIC ACID, INCLUDING: A) CRYSTALIZING THE FORM BY SLOW EVAPORATION OF A SOLVENT OR A SYSTEM OF SOLVENTS; B) CRYSTALIZE FORM B THROUGH SLOW EVAPORATION OF A SOLVENT OR SOLVENT SYSTEM; C) EXPOSE A CRYSTAL FORM B TO A RELATIVE HUMIDITY GREATER OR EQUAL TO 72%; D) GRINDING THE CRYSTAL FORM B AT ROOM TEMPERATURE OR BELOW ROOM TEMPERATURE; E) SUSPEND THE CRYSTAL FORM IN A SOLVENT OR SOLVENT SYSTEM OR; F) SUBLIMATE AND HEAT THE CRYSTALLINE FORM B. SAID CRYSTALLINE FORM IS CHARACTERIZED BY A THERMOGRAM OF THERMOGRAVIMETRIC ANALYSIS THAT HAS A MASS LOSS OF 0.4364% OF THE TOTAL MASS OF THE SAMPLE WHEN HEATED IT BETWEEN 32.9CA DIAGRAM AND A 204.6C THERMORETTAL THERMOGRAM SWEEPING THAT HAVE AN ENDOTHERMAL EVENT WITH A PEAK TEMPERATURE AT 244.24C. THE REFERRED SOLVENT SYSTEM IS SELECTED FROM ACETONITRILE, T-BUTANOL, ISOPROPYL ALCOHOL, ISOPROPYL ETHER, WATER AND A MIXTURE OF THE SAME |