| abstract |
REFERRED TO A COMPOUND OF FORMULA I, WHERE A IS A SYSTEM OF ARYL BICYCLE RINGS OF 9 MEMBERS CONTAINING 0-4 HETEROATOMS OF N, O AND S; R1 IS H, HALOGEN, -CN, C1-C6 ALKYL, AMONG OTHERS; u ES 0-4; B IS A 5-7-MEMBER MONO-CYCLE RING SYSTEM, 8-10-MEMBER BICYCLE RING SYSTEM CONTAINING 0-4 N, O AND S HETEROATOMS; R2 IS H, HALOGEN, C3-C8 CYCLOALKYL, CN, COH2, AMONG OTHERS: v ES 0-4; E IS A SINGLE LINK OR A PYRROLIDINE DERIVATIVE; G IS H, CN, SO2, NH2, C1-C4 ALKYL, AMONG OTHERS. THE PREFERRED COMPOUNDS ARE: (2S) -1- (PHENYLACETIL) -N- {2- [4 - ({[(2S) -1- (PHENYLACETIL) PYRROLIDIN-2-IL] CARBONYL} AMINO) PHENYL] -1H-PIRROLO [3,2-b] PYRIDIN-5-IL} PYRROLIDIN-2-CARBOXAMIDE; {(1R) -2 - [(2S) -2 - ({4- [5 - ({[(2S) -1 - {(2S) -2 - [(TERC-BUTOXICARBONIL) AMINO] -2-PHENYLACETILE} PYRROLIDIN-2-IL] CARBONYL} AMINO) -1H-BENZYMIDAZOL-2-IL] PHENYL} CARBAMOYL) PYRROLIDIN-1-IL] -2-OXO-1-PHENYLETHYL} THIRD-BUTYL CARBAMATE; AMONG OTHERS. SUCH COMPOUNDS ARE USEFUL IN THE TREATMENT OF HCV |