| abstract |
REFERS TO HETEROCICLUS COMPOUNDS OF FORMULA (I) WHERE Y, W, X AND Z ARE EACH CH O N; D AND D1 ARE EACH A LINK OR NRb, WHERE Rb IS H OR RENT; A IS OPTIONALLY REPLACED BICYCLE HETEROARYL; L IS A LINK, -C (O) -, -OC (O) -, -NRbC (S) -, AMONG OTHERS; R1 IS ALKYL, CYCLOALKYL, ARYL, HETEROARYL, AMONG OTHERS, OPTIONALLY SUBSTITUTED WITH Rd, WHERE Rd IS HALO, HALOALCOXY, ALKINYL, NITRO, AMONG OTHERS; R3 IS HALO, HALOALKYL, ALKYL, HYDROXYL, AMONG OTHERS; n, h AND g ARE EACH FROM 0 TO 2. PREFERRED COMPOUNDS ARE: 5-CHLORO-2-METOXY-N- (4- (4- (2-METOXYPHENYL) PIPERAZIN-1-CARBONYL) PHENYL) BENZEN-SULFONAMIDE; N- (4- (4- (2-METOXYPHENIL) PIPERAZIN-1-CARBONYL) PHENYL) NAPHTHALEN-2-SULFONAMIDE; N- (4- (4- (2-METOXYPHENYL) PIPERAZIN-1-CARBONYL) PHENYL) BENZO [d] THIAZOL-5-SULFONAMIDE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE MODULATORS OF PYRUVATE KINASE M2 (PKM2), BEING USEFUL IN THE TREATMENT OF CANCER, DIABETES, OBESITY |