abstract |
REFERS TO COMPOUNDS DERIVED FROM THIOPHENE-2-CARBOXYL OF FORMULA (I) WHERE R1 IS ALKYL (C1-C12), ALKENYL (C2-C12), CYCLOALKYL (C3-C12), AMONG OTHERS; R2 IS ALKINYL (C2-C12), CYCLOALKYL (C3-C12), ARYL (C6-C14), AMONG OTHERS; R3 IS ALKYLENE (C1-C12), ALKENYLENE (C2-C12), ARYLENE (C6-C14), AMONG OTHERS; L IS -O-, -S-, -S (O) -O -S (O) 2-; HET IS HETEROCYCLYL FROM 3 TO 12 MEMBERS OR HETEROARYL FROM 3 TO 14 MEMBERS OPTIONALLY SUBSTITUTED WITH Q4, WHERE Q4 IS HALOGEN, OXO, NO2, N (= O), AMONG OTHERS. PREFERRED COMPOUNDS ARE: 5- (3,3-DIMETHYL-BUT-1-INYL) -3 - {(TRANS-4-METHYL-CYCLOHEXANOCARBONYL) - [TRANS-4- (PIRAZIN-2-ILOXI) -CYCLOHEXYL] - AMINO} -THIOPHENE-2-CARBOXYL; ACID 5- (3,3-DIMETHYL-BUT-1-INYL) -3 - {(TRANS-4-METHYL-CYCLOHEXANOCARBONYL) - [TRANS-4- (6-METHYL-PYRIDAZIN-3-ILOXI) -CYCLOHEXYL] - AMINO} -THIOPHENE-2-CARBOXYL; 5- (3,3-DIMETHYL-BUT-1-INYL) -3 - {(TRANS-4-METHYL-CYCLOHEXANOCARBONYL) - [TRANS-4- (PYRIDIN-3-ILOXI) -CYCLOHEXYL] -AMINO} -THIOPHENE ACID -2-CARBOXYL; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF FLAVIVIRIDAE VIRUSES, BEING USEFUL IN THE TREATMENT OF HEPATITIS C VIRUS (HCV) INFECTION |