| abstract |
REFERRED TO A PHARMACEUTICAL DOSAGE FORM IN THE FORM OF A THERMOFORMED TABLET BY HOT MELT EXTRUSION OF A MIXTURE THAT INCLUDES: a) A PHARMACOLOGICALLY ACTIVE INGREDIENT SUCH AS A SELECTED OPIOID OF OXYMORPHONE OXYMORPHONE AND HYDROPHONE HYDROPHONE, HYDROPHONE HYDROPHONE AND HYDROPHONE HYDROPHONE). A MULTICARBOXYLIC ACID SUCH AS MALEIC ACID, FUMARIC ACID, GLUTARIC ACID, MALONIC ACID AND CITRUS ACID, IN AN AMOUNT OF 0.001% TO 5.0% BY WEIGHT BASED ON THE TOTAL WEIGHT OF THE PHARMACEUTICAL FORM AS TALOX, c) ASCORBIC ACID, ALPHA-TOCOPHEROL, VITAMIN E SUCCINATE, BUTYL HYDROXIANISOL, MONOTHIOGLYCERIN, CONIPHERYL BENZOATE, AMONG OTHERS, AND d) A POLYALKYLENE OXIDE. IT IS ALSO REFERRED TO A PREPARATION PROCEDURE. SUCH DOSAGE FORM HAS A STABILIZED OXIDATION AND IS RESISTANT TO HANDLING AND BREAKING |