| titleOfInvention |
COMBINATION OF PERINDOPRIL AND N - {[(7S) -3,4-DIMETOXIBICICLO [4.2.0] OCTA-1,3,5-TRIEN-7-IL] METIL} -3- (7,8-DIMETOXI-1, 2,4,5-TETRAHYDRO-3H-3-BENZAZEPIN-3-IL) -N-METHYL-3-OXO-1-PROPANAMINE |
| abstract |
REFERS TO A PHARMACEUTICAL COMPOSITION THAT INCLUDES: A) A SELECTIVE AND SPECIFIC INHIBITOR OF SINUS CURRENT If SUCH AS IVABRADINE IN THE FORM OF HYDROCHLORIDE OR N - {[(7S) -3,4-DIMETOXIBICICLO [4.2.0] OCTA-1 , 3,5-TRIEN-7-IL] METHYL} -3- (7,8-DIMETOXY-1,2,4,5-TETRAHYDRO-3H-3-BENZAZEPIN-3-IL) -N-METHYL-3- OXO-1-PROPANAMINE IN THE FORM OF HYDROCHLORIDE OR FUMARATE; AND B) AN INHIBITOR OF ANGIOTENSIN CONVERSION ENZYME SUCH AS PERINDOPRIL IN THE FORM OF A THIRD-BUTYLAMINE OR ARGININE SALT. SUCH COMPOSITION IS USEFUL IN THE TREATMENT OF HEART FAILURE WITH PRESERVED SYSTOLIC FUNCTION |