abstract |
REFERS TO AMINOESTER DERIVATIVE COMPOUNDS OF ALKALOIDS OF FORMULA (I) WHERE R1 IS H, ALKYL (C1-C10), ARYL, CYCLOALKYL (C3-C8), AMONG OTHERS; R2 IS ALKYL (C1-C10), CYCLOALKYL (C3-C8), ARYLALKYL, AMONG OTHERS; R3 IS H, ARYL, HETEROARYL, ARYLALKYL, AMONG OTHERS; R6 IS A COMPOUND OF FORMULA (i), (ii), (iii), AMONG OTHERS, WHERE m AND n ARE FROM 1 TO 3; A- IT IS AN ANION; R4 IS - (CH2) p-P- (CH2) q-W, WHERE p AND q ARE 0 TO 4; P IS ABSENT OR IS O, S, SO, CO, AMONG OTHERS; W IS H, ALKYL (C1-C6), CYCLOALKYL (C3-C8), ARYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: (R) -QUINUCLIDIN-3-ILO 2-PHENYL-2- (PHENYLAMINE) ACETATE; ESTER (R) - (1-AZA-BICYCLE [2.2.2] OCT-3-ILLIC) OF 3-PHENYL-2-PHENYLAMINE-PROPIONIC ACID; (R) -1- (2-PHENOXYETHYL) -3- (2-PHENYL-2- (PHENYLAMINE) ACETOXY) -1-AZONIA-BICYCLE [2.2.2] OCTANE TRIFLUOROACETATE; AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION. THESE COMPOUNDS ARE ANTAGONISTS OF MUSCARINAL RECEPTORS BEING USEFUL IN THE TREATMENT OF ASTHMA, CHRONIC BRONCHITIS, CHRONIC OBSTRUCTIVE PULMONARY DISEASE |