| abstract |
REFERRED TO A CONJUGATE OF FORMULA [ANT-L-Z-] m-T (I); ANT-L-Z-Q (I ') WHERE ANT IS A DERIVATIVE OF ANTHRACICLINE; HE IS A LINKER; Z IS A SPACER SELECTED FROM -NH-, -S-, AMINOALKYLENE, THIOALKYLENE, AMONG OTHERS; m IS 1-30; T IS A SELECTED CARRIER OF PROTEIN, PEPTIDE, MONOCLONAL OR POLYCLONAL ANTIBODY, AMONG OTHERS. A CONJUGATE IS: 2 - [(1- {2-OXO-2 - [(2S, 4S) -2,5,12-TRIHYDROXY-7-METOXY-4 - {[(1S, 3R, 4aS, 9S, 9aR , 10aS) -9-METHOXY-1-METHYLOCTAHYDRO-1H-PYRANE [4 ', 3': 4.5] [1,3] OXAZOLO [2,3-c] [1,4] OXAZIN-3-IL] OXI} -6,11-DIOXO-1,2,3,4,6,11-HEXAHYDROTETRACEN-2-IL] ETOXI} CYCLOHEXYL) OXI] ACETAMIDE. SAID CONJUGATE IS USEFUL IN THE TREATMENT OF CERTAIN TUMORS |