| abstract |
REFERRING TO A CARBOXAMIDE DERIVATIVE OF FORMULA (I), WHERE X IS H, F, Cl, CYANE, NITRO, AMONG OTHERS; AND IT IS H, F, OH, NITRO, AMONG OTHERS; R1 AND R2 ARE C1-C6 ALKYL, C3-C10 CYCLOALKYL, C2-C6 ALKENYL, AMONG OTHERS; R3 H O C1-C6 ALKYL; R4 AND R5 ARE C1-C6 ALKYL, C2-C6 ALKYL, C6-C10 ARYL, AMONG OTHERS; R6 AND R7 ARE (CH2) n-R ', (CH2) n-NR'R ", (CH2) n-NR'COR", AMONG OTHERS; R 'AND R' 'ARE H, C1-C6 ALKYL, C3-C10 CYCLOALKYL, AMONG OTHERS; n IS AN INTEGER FROM 0 TO 6. PREFERRED COMPOUNDS ARE: (2-MORPHOLIN-4-ILETYL) -ACID AMIDE rac- (2R, 3R, 4R, 5S) -3- (3-CHLOROPHENYL) -4- (4 -CHLORO-PHENYL) -4-CYANE-5- (2,2-DIMETHYL-PROPYL) -PYRROLIDINE-2-CARBOXYL, rac- (2S, 3R.4R, 5R) -4- (3-CHLORO-PHENYL) - 3- (4-CHLORO-PHENYL) -2- (2,2-DIMETHYL-PROPYL) -5- [4- (2-MORPHOLIN-4-IL-2-OXO-ETHYL) -PIPERAZINE-1-CARBONYL] - PYRROLIDINE-3-CARBONITRILE, rac- (2S, 3R.4R, 5R) -4- (3-CHLORO-PHENYL) -3- (4-CHLORO-PHENYL) -2- (2,2-DIMETHYL-PROPYL) - 5- [4- (2-OXO-2-PYRROLIDIN-1-IL-ETHYL) -PIPERAZINE-1-CARBONYL] -PYRROLIDINE-3-CARBONITRILE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS INHIBIT THE INTERACTION BETWEEN P53 AND MDM2 PROTEINS AND ARE USEFUL IN THE TREATMENT OF CANCER |