| abstract |
REFERRING TO A HETEROCYCLIC COMPOUND OF FORMULA (I), WHERE n IS 0 O 1; R1 IS PHENYL, PYRIDINE, PYRIMIDINYL, PYRAZINIL, AMONG OTHERS; R2 IS QUINOXALIN-2-IL, BENZOXAZOL-2-IL, 5-CHLORO-1,3-BENZOXAZOLE, PYRIDINE, AMONG OTHERS. PREFERRED COMPOUNDS ARE: (1R, 6S) [8- (4,6-DIMETHYL-PYRIMIDIN-2-IL) -3,8-DIAZA-BICICLO [4.2.0] OCT-3-IL] - (2-THIOFEN- 2-IL-PHENYL) -METHANONE, (1R, 6S) [8- (4,6-DIMETHYL-PYRIMIDIN-2-IL) -3,8-DIAZA-BICYCLO [4.2.0] OCT-3-IL] - (2-FURAN-2-IL-PHENYL) -METHANONE, (1R, 6S) -BIPHENYL-2-IL- [8- (4,6-DIMETHYL-PYRIMIDIN-2-IL) -3,8-DIAZA-BICICLO [4.2.0] OCT-3-IL] -METHANONE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE OREXIN RECEPTOR MODULATORS AND ARE USEFUL IN THE TREATMENT OF DISORDERS OF THE SLEEP AND WATCH CYCLE, METABOLIC AND NEUROLOGICAL DISORDERS, AMONG OTHERS |