abstract |
REFERS TO HETEROCICLIC COMPOUNDS OF FORMULA (A) WHERE X IS OR U S; n IS 1; R1, R3 AND R4 ARE EACH H; R2 IS H, F, METHYL, CF3, AMONG OTHERS; R5 IS F, CHF2, CF2Cl, THIRD-BUTYL, AMONG OTHERS; Y IS ALKYL (C1-C4); T IS CR6 O N; U IS CR7 O N; V IS CR9 O N, WHERE R6, R7 AND R9 ARE EACH H, F, Cl, ALKYL (C1-C4), AMONG OTHERS; W IS CR8, WHERE R8 IS H, F, CN, OH, NH2, AMONG OTHERS; R25 AND R26 ARE EACH H, ISOPROPYL, SEC-BUTYL, METHYL, ETHYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 2- (3-FLUOR-4- (METHYLSULFONAMIDE) PHENYL) -N - ((2-METHYL-6- (TRIFLUORMETHYL) PYRIDIN-3-IL) METHYL) PROPANAMIDE; 2- (3-FLUORINE-4- (METHYLSULFONAMIDE) PHENYL) -N - ((2- (PIPERIDIN-1-IL) -6- (TRIFLUORMETHYL) PYRIDIN-3-IL) METHYL) PROPANAMIDE; 2- (3-FLUORINE-4- (METHYLSULFONAMIDE) PHENYL) -N - ((2-FLUOR-6- (TRIFLUORMETHYL) PYRIDIN-3-IL) METHYL) PROPANAMIDE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE LIGANDS OF THE VANILOID RECEPTOR SUBTYPE 1, BEING USEFUL FOR THE TREATMENT OF CHRONIC PAIN, MIGRANE, NEUROPATHIC PAIN, MULTIPLE SCLEROSIS |