| abstract |
REFERS TO COMPOUNDS DERIVED FROM PYRIDAZINE OF FORMULA (I) WHERE R1 IS ARYL (C6-C14) OR HETEROARYL OF 5 TO 14 MEMBERS OPTIONALLY SUBSTITUTED WITH NH2, CN, OH, AMONG OTHERS; R2 AND R3 ARE EACH ALKYL (C1-C8), ALKYL (C1-C8) -OH OR R2 AND R3 FORM A CYCLOALKYL (C3-C14); L IS A LINK, ALKYLENE (C1-C8), -C (O) O-, ALKYL (C1-C8) -OH, AMONG OTHERS; X AND W ARE EACH N OR CR5, WHERE R5 IS H, HALOGEN, CN, AMONG OTHERS; R7 IS ARYL (C6-C14), HETEROARYL OF 5 TO 14 MEMBERS OR CYCLOHETEROALKYL OF 3 TO 14 MEMBERS; R4 IS ALKYL (C1-C8), ALKENYL (C2-C8), CYCLOALKYL (C3-C14), AMONG OTHERS; Z IS (C1-C8) ALKYL, CN, OH OR HALOGEN; m AND p ARE EACH FROM 0 TO 3; AND IT IS A LINK, ALKYLENE (C1-C8), -C (O) -, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 2 - [(R) -4- (4,5-DIMETHYL-6-PHENOXY-PYRIDAZIN-3-IL) -2-METHYL-3,4,5,6-TETRAHYDRO-2H- [1, 2 '] - BIPIRAZINIL-5'-IL] -PROPAN-2-OL, 2 - [(R) -4- (4,5-DIMETHYL-6-PYRIDIN-4-IL-METHYL-PYRIDAZIN-3-IL) -2-METHYL-3,4,5,6-TETRAHYDRO-2H- [1,2 '] - BIPIRAZINYL-5'-IL] -PROPAN-2-OL, 2 - [(R) -4- (6- BENZYL-4,5-DIMETHYL-PYRIDAZIN-3-IL) -2-METHYL-3,4,5,6-TETRAHYDRO-2H- [1,2 '] - BIPIRAZINYL-5'-IL] -PROPAN-2- OL, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE SMOOTHENED INHIBITORS (SMO), BEING USEFUL IN THE TREATMENT OF TUMOR, CANCER, NEOPLASIA |