| abstract |
REFERS TO A POLYPEPTIDE INCLUDING THE SEQUENCE OF AMINO ACIDS X1X2X3X4X5X6X7X8X9X10X11X12X13X14X15X16X17X18X19X20 (SEQ ID NO: 1) WHERE X1, X7 AND X15 ARE E OR D EACH; X4, X11 AND X18 ARE EACH E, D, A, OR G; X2, X6, X9, X10, X12, X13, X16, X17 AND X20 ARE EACH F, L, W, I, V OR A; X3, X5 AND X19 ARE EACH R, K, OR C; X14 IS R, A, E, or C; AND X8 IS A, GOV, WHERE A IS ALANINE, C IS CYSTEINE, D IS ASPARTATE, E IS GLUTAMATE, F IS PHENYLALANINE, G IS GLYCINE, I IS ISOLEUCINE, K IS LYSINE, L IS LEUCINE, R IS ARGININE, V IS VALINA, W IS TRYPTOPHAN. ALSO THE POLYPEPTIDE INCLUDES A PROTECTIVE GROUP SUCH AS ACETYL, AMIDA, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID POLYPEPTIDE HAS CHOLESTEROL EFFLUX ACTIVITY, INDUCES PRE-BETA FORMATION IN PLASMA, PROTECTS THE OXIDATION OF PHOSPHOLIPIDS, AMONG OTHERS, BEING USEFUL IN THE TREATMENT OF ATHEROSCLEROSIS |