| abstract |
REFERS TO COMPOUNDS DERIVED FROM TRIAZOLOPYRIDINE OF FORMULA (I) WHERE R1 IS H, C (O) ORa, PHENYL OR HETEROARYL, WHERE Ra IS H, ALKYL (C1-C6), CYCLOALKYL (C3-C6), AMONG OTHERS; R2 IS PHENYL, HETEROARYL, OR HETEROCYCLYL; R3, R4 AND R5 ARE EACH H, CH3, CH2CH3, CF3, AMONG THE OTHERS. PREFERRED COMPOUNDS ARE: 5- [3- (PROPAN-2-IL) PHENYL] -N- (2-METHYLPYRIDIN-4-IL) [1,2,4] TRIAZOLO [1,5-a] PYRIDIN-2-AMINE , 4- (5- (3-CHLOROPHENYL) - [1,2,4] TRIAZOLO [1,5-a] PYRIDIN-2-ILAMINO) -N- (PIPERIDIN-4-IL) BENZAMIDE, 5- (4- METOXYPHENIL) -N- (4- (4-METHYLPIPERAZIN-1-IL) PHENYL) - [1,2,4] TRIAZOLO [1,5-a] PYRIDIN-2-AMINE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE INHIBITORS OF JANUS KINASES (JAK2), BEING USEFUL IN THE TREATMENT OF CANCER, DIABETES, ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS |