| abstract |
IT REFERS TO A SOLID PHARMACEUTICAL PREPARATION WHICH IS A MULTILAYER TABLET THAT INCLUDES: A) A PART FORMED BY PARTICLES COATED WITH LACTOSE CONTAINING PIOGLITAZONE, IN WHICH SAID COATED PARTICLES ARE OBTAINED BY A DISCIPLE AND A DISCIPLE, A DISCIPLE, A DISCIPLE, A DISCIPLE OF A PYOGLITAZONE IS OBTAINED BY GRANULATION OF A PAGE OF A BINDER AND LACTOSE IN A SOLVENT; AND B) A PART THAT CONTAINS GLIMEPIRIDE AND A SURFACE ACTIVE AGENT SUCH AS POLYSORBATE 80 THAT IS OBTAINED BY GRANULATION OF AN EXCIPIENT SUCH AS LACTOSE OR CELLULOSE CRYSTALINE WITH A DISPERSION OF GLIMEPIRIDE, A TENSIOACTIVE AGENT, A LIGHTENING AGENT, AND A SOLVENT COLOR WHERE THE BINDER IS HYDROXYPROPYL CELLULOSE AND THE SOLVENT IS WATER. SUCH COMPOSITION IS USEFUL IN THE TREATMENT OF DIABETES |