| abstract |
REFERS TO COMPOUNDS DERIVED FROM PIPERIDINE SUCH AS: ESTER (R) -1- (4-AMINO-3-CHLORO-5-TRIFLUOROMETHYL-BENZYL) -2- [4- (CARBOXIMETHYL-AMINO) -1,4'-BIPIPERIDINIL -1'-IL] -2-OXO-ETHYL ACID FROM 4- (2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZDIAZEPIN-3-IL) -PIPERIDIN-1-CARBOXYL, ESTER ( R) -1- (4-AMINO-3-CHLORO-5-TRIFLUOROMETHYL-BENZYL) -2- (1'-CARBOXIMETHYL-4,4'-BIPIPERIDINYL-1-IL) -2-OXO-ETHYL ACID 4- (2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZDIAZEPIN-3-IL) -PIPERIDIN-1-CARBOXYL, ESTER (R) -1- (4-AMINO-3-CHLORO-5- TRIFLUORomethyl-BENZYL) -2- [4- (4-CARBOXIMETHYL-PIPERAZIN-1-IL) -PIPERIDIN-1-IL] -2-OXO-ETHYL ACID 4- (2-OXO-1,2,4,5 -TETRAHYDRO-1,3-BENZDIAZEPIN-3-IL) -PIPERIDIN-1-CARBOXYL. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE ANTAGONISTS OF THE PEPTIDE DERIVED FROM THE CALCITONIN GENE (CGRP), BEING USEFUL IN THE TREATMENT OF MIGRANA, DIABETES MELLITUS, RHEUMATOID ARTHRITIS, ASTHMA |